Xpert® C. difficile/Epi

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Detection of Clostridium difficile infection with an independent call-out of the 027 strain in around 45 minutes

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10 Tests

GXCDIFF/EPI-10

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Collection devices

Collection Device (Pack of 50)

900-0370

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The Need

Clostridioides difficile infection (CDI) accounts for 15–25% of healthcare-associated diarrhea cases in all healthcare settings¹
It is associated with an increase in length of hospital stay, high morbidity and mortality resulting in both societal and financial burden²
Although the accurate and rapid diagnosis of CDI is essential for effective and timely treatment, this remains an unmet clinical need⁴

1 Lessa FC, Winston LG, McDonald LC, Emerging Infections Program C. difficile Surveillance Team Burden of Clostridium difficile infection in the United States. N Engl J Med. 2015;372:2369–2370.
2 Tschudin-Sutter S, et al. Guidance document for prevention of C. difficile infection in acute healthcare settings. Clin Microbiol Infect 2018;24:1051
4 Bai Y, Hao Y, Song Z, Chu W, Jin Y, Wang Y. Evaluation of the Cepheid Xpert C. difficile diagnostic assay: an update meta-analysis. Braz J Microbiol. 2021 Dec;52(4):1937-1949.

The Solution

The Xpert C. difficile/Epi test provides detection and differentiation of Clostridioides difficile & the epidemic 027strain, in 43 minutes from unformed stool specimens
Rapid detection and differentiation of Clostridioides difficile (CDI) & the epidemic 027 strain optimizes patient management decisions and supports infection control and outbreak prevention measures

The Impact

Rapid and accurate detection of toxigenic C. difficile is essential to diagnose CDI to implement optimized therapy and bed management and to help prevent transmission and outbreaks:
– 45% reduced empiric therapy5
– 48% reduced isolation days6

3 Markovska, R et al. Clostridioides difficile, a new suberbug, Microorganisms 2023, 11, 845. https://doi.org/10.3390/microorganisms11040845
5 Peppard W, et al. Implementation of polymerase chain reaction to rule out C. difficile infection is associated with reduced empiric antibiotic duration of therapy. Hosp Pharm. 2014 Jul;49(7):639-43.
6 Casari E, et al. Reducing rates of Clostridium difficile infection by switching to a stand-alone NAAT with clear sampling criteria. Antimicrob Resist Infect Control. 2018 Mar;7(40)